TED QSP Model (prototype)

Drug / mechanism

Overlay no-treatment natural history

Body weight (kg)

Sex (affects teprotumumab Vc)

Baseline disease severity (TRAb-relative)

Days since TED onset (at simulation start)

Natural-history burnout time constant (days)

Dose (mg/kg)

Number of doses

Interval between doses (days)

Simulation length (days)